Zofran (ondansetron): Basics, Side Effects & Reviews

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common



fast heartbeat



shortness of breath


Less common

Decrease in the frequency of urination

decrease in the urine volume

difficulty with passing urine (dribbling)

painful urination


Arm, back, or jaw pain

chest pain or discomfort

chest tightness or heaviness



decreased urine

difficulty with breathing

difficulty with swallowing

dry mouth

fast, pounding, or irregular heartbeat or pulse

increased thirst

loss of appetite

loss of bladder control

loss of consciousness

mood changes

muscle pain or cramps

nausea or vomiting

noisy breathing

numbness or tingling in the hands, feet, or lips

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

skin rash, hives, or itching


tightness in the chest

total body jerking

unusual tiredness or weakness


Incidence not known

Blurred vision

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

fixed position of the eye

heart stops


inability to move the eyes

increased blinking or spasms of the eyelid

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

no breathing

no pulse or blood pressure

noisy breathing

pounding heartbeat

slow or irregular breathing

sticking out of the tongue


trouble with speaking


uncontrolled twisting movements of the neck, trunk, arms, or legs

unusual facial expressions

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common


difficulty having a bowel movement (stool)

dry mouth

general feeling of discomfort or illness





trouble sleeping


Difficulty with speaking


loss of balance control

muscle trembling, jerking, or stiffness

shuffling walk

stiffness of the limbs

twisting movements of the body

uncontrolled movements, especially of the face, neck, and back

Incidence not known

Feeling of warmth


redness of the face, neck, arms, and occasionally, upper chest

redness of the skin


Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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