Hashimoto ’ sulfur thyroiditis is a more common cause of goiter formation in the US. This is an autoimmune condition in which there is end of the thyroid gland by one ’ randomness own immune system. As the gland becomes more damage, it is less able to make adequate supplies of thyroid hormone. The pituitary gland senses a depleted thyroid hormone horizontal surface and secretes more TSH to stimulate the thyroid. This stimulation causes the thyroid to grow, which may produce a goiter.
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Another common cause of goiter is Graves ’ disease. In this case, one ’ randomness immune arrangement produces a protein, called thyroid stimulating immunoglobulin ( TSI ). As with TSH, TSI stimulates the thyroid gland to enlarge producing a goiter. however, TSI besides stimulates the thyroid to make besides much thyroid hormone ( causes hyperthyroidism ). Since the pituitary senses excessively much thyroid hormone, it stops secreting TSH. In malice of this the thyroid gland continues to grow and make thyroid gland hormone. consequently, Graves ’ disease produces a goiter and hyperthyroidism.
Multinodular goiters are another coarse causal agent of goiters. Individuals with this disorder have one or more nodules within the gland which induce thyroid expansion. This is much detected as a nodular feel gland on physical examination. Patients can present with a individual large nodule or with multiple smaller nodules in the gland when beginning detected ( see Thyroid Nodule booklet ). therefore, in early stages of a multinodular goiter with many belittled nodules, the overall size of the thyroid gland may not be enlarged yet. Unlike the other goiters discussed, the cause of this character of goiter is not well understand.
Reading: American Thyroid Association
In addition to the common causes of goiter, there are many other less coarse causes. Some of these are due to genic defects, others are related to injury or infections in the thyroid, and some are due to tumors ( both cancerous and benign tumors ) .