High Creatinine Symptoms: What May Occur When Your Levels Are Off

What is creatinine?

Creatinine is a waste merchandise that ’ s made by your muscles. Your kidneys work to filter creatinine deoxyadenosine monophosphate well as early consume products out of your blood. After being filtered, these pine away products are then expelled from your body in urine. Measuring creatinine levels can provide significant insights into how your kidneys may be functioning. Your repair can measure creatinine levels in both your blood and in your urine. Creatinine levels that are above or below normal ranges may indicate the presence of a health condition. Let ’ s take a closer attend at high creatinine, the symptoms that go along with it, and when to see a doctor.

Normal and high ranges

Creatinine levels can be determined using a blood examination or a urine test .

Blood creatinine test

You may besides see this test referred to as a serum creatinine test. During this test, lineage is collected from a vein in your arm and is then sent to a lab for promote analysis. According to Mayo Clinic, the convention scope of creatinine ( for an adult ) in the blood is typically :

  • U.S. units: 0.84 to 1.21 milligrams per deciliter (mg/dL)
  • European units: 74.3 to 107 micromoles per liter (umol/L)

Creatinine levels above the normal compass values may be considered high. Your doctor of the church may want to confirm these values by using a urine test or by repeating the blood test .

Urine creatinine test

Your repair may collect a random ( single ) urine sample for this test, but they ’ ll more likely request a 24-hour sample. A 24-hour urine sample involves collecting your urine over a period of 24 hours. According to Mayo Clinic Laboratories, the normal urine creatinine ranges in a 24-hour urine sample distribution are :

  • U.S. units: 955 to 2,936 milligrams per 24 hours (mg/day) for men; 601 to 1,689 mg/24 hours for women
  • European units: 8.4 to 25.9 millimoles per 24 hours (mmol/day) for men; 5.3 to 14.9 mmol/day for women

Urine creatinine levels above these ranges are considered high, and extra test or repeat test may be required. The amount of creatinine in the urine can besides be used in conjunction with serum creatinine results to calculate your creatinine clearance, which measures how well your kidneys are filtering your lineage .

A Note on reference ranges and Results Creatinine levels may vary due to factors like by historic period, arouse, raceway, hydration, or body mass. additionally, standard citation ranges can vary from lab to lab. It ’ mho significant that you don ’ thymine try to interpret your results on your own. Your repair will work with you to evaluate and interpret your results and what they may mean .

Symptoms that can accompany high creatinine

The symptoms of senior high school creatinine can depend on the condition that ’ s causing it .

Drug toxicity (drug-induced nephrotoxicity)

Some medications can cause damage to the kidneys and impair their ability to function. Examples of such drugs are :

  • antibiotics, such as aminoglycosides, rifampin, and vancomycin
  • cardiovascular drugs, such as ACE inhibitors and statins
  • chemotherapy drugs
  • diuretics
  • lithium
  • proton pump inhibitors

Symptoms that go along with high creatinine and can develop quickly may include :

  • fluid retention, particularly in your lower body
  • passing low amounts of urine
  • feeling weak or fatigued
  • confusion
  • nausea
  • shortness of breath
  • irregular heart rate
  • chest pain

Kidney infection (pyelonephritis)

A kidney infection is a character of urinary tract contagion ( UTI ). It can happen when bacteria or viruses infect other parts of your urinary nerve pathway before moving up into the kidneys.

If left untreated, kidney infections can cause damage to your kidneys and even kidney failure. Some kidney infection symptoms to look out for include :

  • fever
  • pain localized to your back, side, or groin
  • urination that’s frequent or painful
  • urine that appears dark, cloudy, or bloody
  • bad-smelling urine
  • chills
  • nausea or vomiting


Glomerulonephritis occurs when the parts of your kidneys that filter your lineage become inflamed. Some electric potential causes include infections or autoimmune diseases like lupus and Goodpasture syndrome. glomerulonephritis can lead to kidney scar and damage angstrom well as kidney failure. Symptoms of the condition include :

  • high blood pressure
  • blood in the urine, which may make it appear pink or brown
  • urine that appears foamy due to high levels of protein
  • fluid retention in the face, hands, and feet


Diabetes is a condition in which your blood sugar is besides gamey. Elevated blood boodle levels can lead to a variety of health problems, one of which is kidney disease. There are two types of diabetes — type 1 and type 2. Symptoms of type 1 diabetes can develop promptly while symptoms of type 2 often develop gradually. General symptoms of diabetes include :

  • feeling very thirsty
  • frequent urination
  • increased appetite
  • feeling fatigued
  • blurry vision
  • sensations of numbness or tingling in the hands and feet
  • slow wound healing

High blood pressure

high blood pressure happens when the coerce of the lineage pushing on the walls of your arteries is besides high gear. This can damage or weaken the blood vessels around the kidneys, impacting kidney function and causing high gear creatinine. Since gamey blood pressure frequently has no symptoms, many people don ’ t know they have it. It ’ s much detected during a everyday health screen .

Heart disease

Conditions affecting the heart and lineage vessels, such as atherosclerosis and congestive heart failure, can besides impact kidney serve. These conditions can affect blood flow through the kidneys, leading to damage or personnel casualty of function. Symptoms of atherosclerosis don ’ metric ton normally occur until an artery is hard specialize or completely blocked. They can besides depend on the character of artery affected. Some general symptoms include :

  • chest pain (angina)
  • shortness of breath
  • abnormal heart beat (arrhythmia)
  • feeling tired or weak
  • stroke-like symptoms, such as paralysis or trouble speaking

Symptoms of congestive center failure can include :

  • difficulty breathing or shortness of breath
  • feeling tired or fatigued
  • swelling in the abdomen, legs, or feet

Urinary tract blockage

Your urinary tract can become obstruct due to a assortment of things, such as kidney stones, an blown-up prostate, or tumors. When this happens, urine may accumulate in the kidneys, leading to a condition called hydronephrosis. Symptoms of a urinary tract blockage can develop promptly or lento over time depending on the causal agent. Some signs to look out for in addition to a high creatinine grade include :

  • pain in your back or side
  • frequent or painful urination
  • blood in your urine
  • passing small amounts of urine or having a weak urine stream
  • feeling tired or fatigued

Kidney failure

Kidney failure refers to a decrease in kidney function and one of the most common causes of high creatinine. It can be either acute or chronic. The symptoms of acute kidney failure can come on quickly while those of chronic kidney failure develop over time. Some symptoms of kidney failure to watch for include :

  • fluid retention, particularly in your lower body
  • passing low amounts of urine
  • feeling weak or fatigued
  • headache
  • confusion
  • nausea
  • trouble sleeping
  • muscle cramping
  • feeling itchy
  • shortness of breath
  • chest pain

When to see a doctor

You should always call your repair if you ’ re experiencing new, unexplained, or recurring symptoms, particularly if they ’ ra consistent with conditions such as kidney disease, diabetes, or heart disease. Your doctor will work with you to evaluate your symptoms and determine the treatment that ’ s right for you. It ’ sulfur important to remember that breast trouble and acute accent kidney failure should constantly be taken badly. You should be sure to seek immediate aesculapian attention if you ’ ra experiencing either one.

What’s the outlook of high creatinine?

There are many potential causes of high creatinine levels. additionally, the symptoms of high creatinine can vary depending on the campaign. In many cases, medications can help resolve high creatinine levels by treating the condition that ’ s causing the increase. Some examples include antibiotics for a kidney infection or medications that assistant control gamey rake pressure. In cases of kidney failure, dialysis may be required in addition to medications to help percolate toxins and waste products from your lineage. In severe cases or end-stage cases, a kidney transfer may be required .

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